Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary Targetcytochrome c oxydase

Product does not compete with ATP.

Kd = 270 nM in binding with cytochrome c oxidase

General description

Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. ~100 times more effective than 2,4-dinitrophenol. Binds cytochrome C oxidase with high affinity (K_d = 270 nM). Inhibits transport processes and depresses growth.

Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (K_d = 270 nM). Inhibits transport processes and depresses growth.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun.7, 272.

Packaging

250 mg in Plastic ampoule

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

Warning

Toxicity: Harmful (C)